TCR and BCR profiling holds great potential not only for understanding the development mechanisms of the normal immune response but also for providing insight into disease mechanisms and the development of new therapies for infectious diseases.48 In this study, clonotypic T cell expansion was reduced during disease recovery, while clonotypic B cell expansion rose simultaneously, suggesting the acute effective immune response goes down after virus removal and antibodies will likely stay for quite a long time to protect the host from reinfection. The gene discussed is BCR; the disease is infectious disease.