TNF and infection: TNF signaling pathway (hsa04668) and NF-kappa B signaling pathway (hsa04064) directly involved in immunity, inflammation and modulation of immune responses, were identified only in CoPS vs. H comparison what is maybe be associated with the different mode of action and ability to survive in the host’s organism of these two groups of bacteria [4] as well as with the production capability of toxins that are also important virulence factor in infection pathogenesis [5].