Notably, CYP27A1-overexpressing mice that produce increased levels of 27-OH develop memory impairment due to, e.g., reduction in neuronal glucose uptake [29], impaired neuronal branching and reduced synaptic density [30], inflammation and impairment of the brain renin-angiotensinogen system [24]. The gene discussed is CYP27A1; the disease is memory impairment.