In several tumor types, GMD expression was associated with methylation of the regions of MLKL and RIPK3 encoding key players in necroptosis [118], RIPK2 and RIPK4, which are involved in inflammatory signaling and NF-κB activation [119, 120], and IRAK2, IRAK3, and IRAK4, which mediate the toll-like receptor and interleukin-1 receptor signaling pathways and are involved in the NF-κB activation [121] (Additional file 9: Table S9; Additional file 19: Data S1). This evidence concerns the gene IRAK4 and neoplasm.