IRAK2 and neoplasm: Its methylation was associated with expression of multiple GMDs including TET3, TDG, SETDB1, ZBTB38, KDM2B, and CBX2. Multiple probes and regions in other target genes, e.g., ABL2, SP1, DAPK3, NF1, IRAK2, UBE2O, and FTO, which were associated with drug response in the pancancer data, also had strong associations in individual tumor types (|ρ| > 0.5; Additional files 14, 15: Tables S14 and S15).