WWTR1 and small cell lung carcinoma: It is consistent with an earlier report by an independent group using SCLC CCLE cell lines and with our previous findings in the NCI SCLC dataset, which showed that increased methylation and low expression of the genes encoding TEAD co-activators YAP1 and TAZ in the Hippo pathway in SCLC were associated with resistance to multiple mTOR inhibitors [86, 147, 148].