For example, APOBEC2 expression in bladder cancer was associated with methylation of the 5′ UTR and the 1st exon of the DNA demethylase ALKBH2, whose product removes N1-meA and N3-meC (ρ = − 0.8687; Additional files 1, 9: Tables S1 and S9) [38, 39]. The gene discussed is APOBEC2; the disease is urinary bladder carcinoma.