Expression of UHRF1, whose product has multiple roles in DNA methylation including interactions with DNMT1, DNMT3a, DNMT3b and G9a, control of DNMT1 abundance, and targeting DNMT1 to hemimethylated DNA during replication (Additional file 1: Table S1) [24, 25, 32, 40, 115], was strongly associated with methylation of multiple probes and regions in many tumor types (Table 3; Additional file 21: Fig. S1; Additional files 10, 11: Tables S10 and S11). This evidence concerns the gene DNMT3B and neoplasm.