Panobinostat sensitivity was also correlated with methylation of a probe and the entire TSS1500 in NNMT, which controls the methylation potential of tumor cells [112], consistent with NNMT upregulation in a panobinostat resistant glioma cell line [139] and with the correlation of NNMT expression with vorinostat resistance [140]. This evidence concerns the gene NNMT and glioma.