Consistent with their roles in DNA methylation and with the direction of associations in the pancancer dataset, DNTM1, DNMT3A, and DNTM3B expression was associated with increased methylation of many individual probes and gene regions in multiple tumor types (Table 3; Additional file 21: Fig. S2; Additional files 10, 11: Tables S10 and S11). Here, DNMT3A is linked to neoplasm.