F3 and Thromboembolism: Previous study had confirmed that tissue factor [6] has a critical role in promoting MSC-mediated coagulation in living animals and that its expression is likely to lead to thromboembolism and subsequent death of a patient treated with MSCs [25], as TF is highly expressed at the level of mRNA and localized to the cell surface of cultured MSCs, a triggering factor in the procoagulative cascade activated by infused MSCs [25].