FBXW7 and neoplasm: To validate whether FBXW7 contributes to the anti-tumor phenotype regulated by METTL3, we generated stable cells expressing the indicated genes (Fig. 3b, Additional file 1: Fig. S3B) to determine whether FBXW7 overexpression could rescue the effects of METTL3 knockdown on the biological behavior of HCC827 or PC9 cells.