According to our study, an autophagy-related independent prognostic signature is constructed by 5 ARGs with different coefficients, including PEX3, DNAJB9, RB1, HSP90AB1 and CXCR4. There were only a few researches reported a relationship between the 5 ARGs and cancers, Daniela et al and Shaobo et al reported PEX3 plays an important role in Melanoma [29] and colon cancer [30] respectively. This evidence concerns the gene CXCR4 and malignant colon neoplasm.