Another promising strategy was demonstrated by H. Uludağ and coworkers who statistically incorporated hydrophobic moieties into polymeric nanocarriers that were beneficial for the transfection of siRNA and subsequent knockdown of the BCR-ABL fusion protein in the CML cell line K-562 [19–21]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.