Besides, the patients with higher PRG tended to have higher levels of CEA and CA19-9, and have greater possibility of VI and lymph node metastasis, all of which had been widely considered to be associated with poor prognosis of ICC and were the indications of and systemic therapy for ICC [3, 4, 26, 27]. The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.