Besides, the C-index of the multivariate prognostic model only consisting of the tumor-specific factors (CEA, CA19-9 and tumor number) could be improved to 0.737 (95% CI 0.062–0.768) from 0.625 (95% CI 0.585–0.665) when the PRG was incorporated (p < 0.001). This evidence concerns the gene CEACAM5 and neoplasm.