According to the online database prediction, AC063977.6 directly targets miR-338-3p, whereas miR-338-3p directly targets PFKFB2, suggesting that AC063977.6, miR-338-3p, and PFKFB2 might form an axis that modulates NP cell metabolism in IDD. The gene discussed is PFKFB2; the disease is intervertebral disk degenerative disorder.