Although some reports have indicated that high LGR5 expression is associated with a poor prognosis [18, 19], others have used RNAscope, which is considered to be more reliable [20, 21], and have reported that high LGR5 expression correlates with a good prognosis specifically in pancreatic ductal adenocarcinoma [21]. This evidence concerns the gene LGR5 and pancreatic ductal adenocarcinoma.