In both glomerulonephritis and RCC, epithelial cells and/or tumor cells produce CCL2 [53, 100], M-CSF [54, 101], and IL-8 [66, 97], which recruit monocytes and macrophages, promote monocyte-to-macrophage differentiation, and recruit neutrophils, respectively. This evidence concerns the gene CXCL8 and renal cell carcinoma.