Multiple risk factors for CIN have been studied, from biomarker including NGAL, KIM-1, NAG to various clinical models such as Merhan risk score, Marenzi’s simple risk score, Mosquera’s 5 factor score etc. containing age, comorbidities, baseline renal function, hydration usage, contrast volume and so on [8, 15, 16]. This evidence concerns the gene LCN2 and cervical squamous intraepithelial neoplasia.