BRK1 and hereditary pheochromocytoma-paraganglioma: Other genes deleted include FANCD2 (7 deletions), CICECP and EMC3 (2), and PRRT3, CRELD1, IL17RC, IL17RE, JAGN1, and CIDEC (1) upstream of VHL and IRAK2 (15) and TATDN2 (3) downstream of VHL. Families with deletions that extended to include FANCD2 (and BRK1) upstream or IRAK2 downstream did not demonstrate a phenotype that is noticeably different from those with smaller deletions, other than that deletions involving FANCD2 have a lower incidence of kidney solids and retinal angiomas, and no pheochromocytomas, similar to what has been seen in the deletion of BRK1 alone (Franke et al., 2009).