In the advanced stage of the disease, critically ill COVID‐19 patients develop a cytokine storm where many inflammatory mediators using the JAK/STAT signaling pathway such as IL‐6, IFN‐γ, the granulocyte colony‐stimulating factor (G‐CSF) or IL‐2, and chemokines result in an influx of macrophages and neutrophils damaging the lung tissue. The gene discussed is IFNG; the disease is COVID-19.