SMARCA4 and thymoma: However, no recurrent genetic alterations were identified even in heavily pretreated thymomas, while TC frequently showed mutations in potential oncogenic driver genes with a role in chromatin remodeling (e.g., SMARCA4), histone modification (BAP1, SETD2, ASXL1), and DNA methylation (TET2, DNMT3a34, WT1).