AIRE and thymoma: By contrast, multiomics molecular analysis revealed that thymoma-associated MG is linked to aneuploidy and over-expression of genes that encode either bona fide (e.g., AChR) or closely related (e.g., neuronal RYRs) autoimmune targets [10], while other defective tolerogenic features (e.g., the lack of AIRE expression [11–14] and defective intratumorous generation ofregulatory T cells [12, 15, 16]) might be permissive but not causative [10], although this is controversial [17].