CXCR2 and inflammatory bowel disease: For example, receptors of the CXC ligand 8 (CXCL8 or IL8) chemokine family, CXCR1 and CXCR2, were overexpressed while their known negative modulator compounds, ibuprofen (pxC50 = 7.0) and its HMP-2 derivative, 2-hydroxibuprofen, (Supplementary Data 3), were under-represented in IBD patients although below the consensus scoring threshold (Supplementary Data 1).