Compared with the HC group, plasma NfL was elevated in sCJD (z = 11.8, p < 0.0001), symptomatic IPD (z = 5.7, p < 0.0001), vCJD (z = 4.5, p = 0.0001), and iatrogenic CJD (z = 6.3, p < 0.0001). The gene discussed is NEFL; the disease is variant Creutzfeldt-Jakob disease.