For example, among the “collagen degradation” (R-HSA-1442490) enriched pathway genes (Supplementary Data 3E), COLA1 (collagen type I chain), other members of the collagen gene family (COL4A2 COL16A1 COL4A4 COL6A2 COL6A1 COL5A1 COL9A1 COL13A1 COL12A1 COL1A2) were all significantly downregulated in COVID-19 diseased lungs when compared with expression in lungs of uninfected controls. The gene discussed is COL5A1; the disease is COVID-19.