Patients with Wnt mutations involving (1) LRP5 (may be also associated with low bone mineral density), (2) NDP, (3) FZD4, and (4) TSPAN12 may develop a variety of retinal vascular diseases including Familial Exudative Vitreoretinopathy (FEVR), Norrie Disease (NDP mutation), and others [64]. The gene discussed is LRP5; the disease is Familial exudative vitreoretinopathy.