Both chronic and acute DSS-induced colitis older mice also showed changes in metabolic parameters in the similar pattern to that of younger mice, i.e., significant reductions in expression of adiponectin and adiponectin receptor (in SAT and MAT), PGC-1α and irisin (in muscle), lipogenic genes (in the liver), genes related to lipid oxidation and lipolysis (in the liver, SAT, and MAT), and genes involved in adipocyte browning (in SAT), compared to non-colitis controls (Fig. 7A–K). Here, FNDC5 is linked to colitis.