Our data showing a downregulation of adiponectin, AdipoR1, and AdipoR2 in the liver and adipose tissues and a reduction in AMPK activation in the liver of DSS-induced colitis mice (Fig. 2I–L), together with reduced expression of SIRT1 (Fig. 2H), suggest that colitis might cause a disturbance in adiponectin-AMPK-SIRT1 mediated metabolic regulation. Here, ADIPOR1 is linked to colitis.