Despite significant increases in the liver weight and hepatic fat accumulation as shown in Fig. 2A–C, we unexpectedly observed that the expression of genes involved in de novo lipogenesis such as PPARγ, SREBP1c, ACC, FAS, and SCD1, DGAT1, DGAT2, and GPAT was significantly decreased in the liver of DSS-induced colitis mice compared to non-colitis controls (Fig. 3A). Here, SREBF1 is linked to colitis.