The results of this study demonstrate that DSS-induced colitis is associated with suppressed gene expressions related to SAT browning and BAT thermogenesis (Figs. 5A–C, 7K,L), and their master regulators, PPARα and PGC-1α (Figs. 3D, 5C, 7F,L) in both SAT and BAT. This evidence concerns the gene PPARA and colitis.