DSS-induced colitis mice also showed significant decreases in expression of genes related to lipid oxidation, including PPARα and PGC-1α, and their target genes Acox1, CPT1, and MCAD, as well as lipolytic genes including LPL, ATGL, MGL, and HSL, in the liver, SAT, and MAT compared to non-colitis control mice (Fig. 3C–F,H,I). Here, PNPLA2 is linked to colitis.