Further reinforcing the idea that transcriptomics has a role in the molecular classification of fusion driven sarcomas, the same group showed that consensus clustering of gene expression data in endometrial stromal sarcomas (ESS) was capable of identifying a high grade group comprised of tumours harbouring BCOR rearrangements, and a low grade group composed of tumours with a fusion of a PRC2 zinc finger protein (such as JAZF1 and PHF1)26. The gene discussed is ZNF146; the disease is endometrioid stromal sarcoma.