Four of 268 patients (1.5%) with leukemia carried pathogenic or likely pathogenic variants in TP53, BRCA2, PALB2, and PMS2. Only TP53 is associated with susceptibility to leukemia21, although pathogenic variants in BRCA2 and PALB2 have been reported previously in leukemia patients. The gene discussed is PMS2; the disease is leukemia.