FGFR4-knockdown markedly suppressed cell growth in Huh7 and JHH7 cells (FGF19+FGFR4+ HCC cells), but not in HepG2 and PLC/PRF/5 cells (FGF19−FGFR4+ cells). This evidence concerns the gene FGFR4 and hepatocellular carcinoma.