Interestingly, all seven of the 14-3-3 family of proteins; two of the IQGAP family of proteins (IQGAP1 and IQGAP2); four of the 36 human SERPIN proteins (SERPINA1; SERPINA3; SERPINB1 and SERPINH1); four of the S100 proteins (S100A8; S100A9; S100A10 and S100A11); six of the 12 Annexin proteins (ANXA1-6); two of the ezrin/radixin/moesin (ERM) family of proteins (EZN and MSN); three of the 12 aldehyde dehydrogenase protein family (ALDH1A1; ALDH2 and ALDH9A1); and four of the 11 human cathepsins (CSTB, CSTD; CSTG and CSTZ) were conserved across the three cancers. The gene discussed is CSTB; the disease is cancer.