Finally, we addressed the relevance of these findings to the human disease by assessing the relationship between circulating GRANZYME B levels and clinical outcomes among those 1046 patients (Supplementary Table 2) who contributed to a serum bank in FAST-MI, a nationwide cohort of consecutive adults with ST-segment-elevation or non-ST-segment-elevation MI hospitalized at intensive care unit with symptom onset ≤48 h, in 213 centers representing 76% of French centers managing acute MI patients (NCT01237418). This evidence concerns the gene GZMB and myocardial infarction.