Gene ontology (GO), using the Ingenuity Pathway Analysis (IPA) for each category, showed that the genes belong to diverse signaling pathways, including IL-10 signaling, Alzheimer’s disease signaling, AMPK signaling, cAMP signaling, Rho GTPase signaling, and the matrix metalloprotease, EIF2, and mTOR pathways (Supplementary Fig. S10B). The gene discussed is IL10; the disease is early-onset autosomal dominant Alzheimer disease.