Corresponding with these findings, the implanted tumor volume and weight significantly decreased in the co-treatment group of 5-Aza/MS275 and radiation compared to the radiation-only group (Supplementary Fig. 3, A, B), which was correlated with an increased enrichment of H3K9ac and H3K4me3 and a decline of H3K27me3 to the p62 promoter region (Supplementary Fig. 3, C–E). Here, SQSTM1 is linked to neoplasm.