TP53 and neoplasm: In contrast, accordingly with previous results [13], p53-null H1299 (Fig. 1c) and p53-depleted (sh/p53) A549 NIR tumors (Fig. 1d,f) showed no significant effects on tumor growth, as it almost overlapped that of the respective controls UnIR tumor group, thus confirming that functional p53 is required to trigger AE in vivo after high-dose radiation.