It has been shown that, the expression of p62 of the mRNA found in TCGA melanoma, and the factors of NF-κB signaling, including NFKB1, RELA, or MELK, the stability of mTOR-related genes such as S6K1, the cytoprotective agent NRF2, or the transcription factor MYC as well as mRNAs encoding FERMT2 and other pro-metastatic factors, can affect the process of melanoma development and can be used as important therapeutic targets in the future [69]. The gene discussed is NFKB1; the disease is melanoma.