For example, the expression level and methylation of AREG in cancer tissues depend on the grade of astrocytoma [30]; insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) can predict the poor prognosis of high-grade astrocytoma [31]; CHI3L1 mRNA expression can be used as a biomarker for the prognosis of glioma patients [32]. This evidence concerns the gene IGF2BP3 and central nervous system cancer.