MBD2 and glioblastoma: In addition, ALKBH5, a demethylase of m6A, can regulate the proliferation and self-renewal of glioblastoma stem-like cells by regulating the stability of pre-mRNA and the expression of FOXM1 gene [22]; FTO, a demethylase of another m6A, is also considered to have the potential to be a new target for glioblastoma therapy [23].