RYR2 and channelopathy: Sufficient clinical data was not available to verify the accuracy of the HCM diagnoses in patients with a LP/P variant in LMNA, JUP, DSG2, SCN5A, RYR2, TRPM4 or NF1. Diagnostic variants in the broad cardiomyopathy panel were the most varied and were distributed across all gene categories (sarcomere, RASopathy, non-sarcomere HCM, metabolic/storage, other cardiomyopathy, channelopathy/arrhythmia and syndromic/myopathy).