PYHIN1 and asthma: On the other hand, the EVE Consortium identified a susceptibility locus for asthma in the PYHIN1 gene on chromosome 1q23 (pyrin and HIN domain family member 1; a major mediator of the tumor suppressor activity of IFN in breast cancer cells) that was unique in individuals of African descent with the marker rs1102000 being most strongly associated with asthma [20].