The meta-analysis identified as the 5 most significant loci on chromosomes 17q12-21 near PGAP3 and ERBB2, 6p21.32 near HLA-122 DRB1/-DQA1, 5q22.1 near TSLP, 2q12 near IL1RL1/IL18R, and 9p24.1 near IL33 in both the whole sample and in the subset that included only subjects with early-onset asthma [16]. The gene discussed is IL1RL1; the disease is asthma.