Support for the FKBP5 gene-environment interaction model in schizophrenia comes from evidence for: (a) elevated cortisol levels in schizophrenia [16]; (b) impaired negative feedback observed in schizophrenia, leading to an excessive and prolonged stress response [17]; (c) reduced GR expression in hippocampus, frontal cortex, inferior temporal cortex [18] and amygdala samples of individuals with schizophrenia [19]. The gene discussed is FKBP5; the disease is schizophrenia.