Among them are TRIM2 (up-regulated in osteosarcoma, down-regulated in kidney cancer), TRIM29 (up-regulated in lung cancer and osteosarcoma, down-regulated in liver and prostate cancers), TRIM33 (up-regulated in breast cancer, down-regulated in liver and kidney cancers) [135,136,137,138,139,140,141,142,143]. The gene discussed is TRIM33; the disease is osteosarcoma.