TRIM8 seems to be down-regulated in CRC and in restoring TRIM8 levels, p53 is stabilized, and cells become sensitive again to chemotherapeutics (The Human protein Atlas, available from http://www.proteinatlas.org, accessed on 25 February 2021) [151,182,229,237] (Table 2). This evidence concerns the gene TRIM8 and colorectal carcinoma.