NFKB1 and neoplasm: Contrary to oncogenic TRIMs, there are also some tumor suppressors, TRIMs protein that are able to antagonize NF-kB activity by promoting inhibitor of nuclear factor kappaB kinase subunit gamma (IKKγ) neddylation with the consequent stabilization of the IκBα protein and the impairing of the NF–κB activation, even in the presence of NF-κB activating cytokines [228].