TRIMs 3, 8, 13, 16, 21, 62 are downregulated in many of the main cancers worldwide (breast, gastric, liver, lung, osteosarcoma, prostate, kidney) [120,121,122,123,124,125,126,127,128,129,130,131], while some TRIMs are under-expressed in a cancer-specific way (e.g., TRIM15 in gastric cancer, TRIM26 in liver, TRIM58 in lung). Here, TRIM58 is linked to cancer.