TRIM8 and central nervous system cancer: As in breast cancer, and also in other cancers, low expression levels of TRIM8 are associated with a poor prognosis for the patients; in fact, TRIM8 is downregulated in Glioma, Chronic lymphocytic leukemia (CLL), Renal Clear Cell Carcinoma (ccRCC), CRC and in melanoma [148,150,247,248,249].