TRIMs 11, 14, 22, 24, 25, 27, 28, 32, 37, 44, 47, 49, 59, 65 are upregulated in some of the high incidence cancers (breast, gastric, liver, lung, osteosarcoma, prostate, kidney) [73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114], while some others TRIM are upregulated in a cancer-specific way (e.g., TRIM22 in lung, TRIM31 and TRIM35 in liver, TRIM63 in breast, TRIM66 in osteosarcoma, TRIM68 in prostate). The gene discussed is TRIM22; the disease is osteosarcoma.