EEF2K and neoplasm: Compound 28 was further found to be weakly anti-proliferative in vitro against MDA-MB-231 cells and MDA-MB-436 cells with IC50 values of 12.6 and 19.8 μM, respectively, and most notably demonstrated in vivo efficacy inhibiting tumor growth by inducing apoptosis via eEF2K inhibition in the xenograft mouse model of TNBC with the same two cell lines [94].