Strikingly, while high expression of the majority of Wnt/CSC-associated genes correlated with good prognosis, the CSC population of these poor-prognosis tumours expressed an immature, embryonic stem cell-like signature, distinguished by markers of pluripotency (namely, targets of the transcriptional regulators SOX2, OCT4, and NANOG) as well as the selective methylation of Wnt/CSC-associated genes [352]. This evidence concerns the gene NANOG and neoplasm.