While L1CAM knockdown does not impact adenoma initiation per se, it significantly inhibits the growth, chemoresistance, and metastatic ability of orthotopically implanted organoids derived from either left-sided APC-mutant or right-sided BRAF-mutant tumours, underscoring that distinct primary tumour types may nevertheless deploy similar tactics to navigate the metastatic cascade. The gene discussed is APC; the disease is adenoma.