Furthermore, converging evidence suggests that activated CAFs elaborate a cocktail of cytokines, including HGF, OPN, SDF1, and IL17A, which stimulates Wnt/β-catenin signalling and confers enhanced clonogenic potential, therapy resistance, and metastatic competence upon nearby CSCs as well as bestowing CSC traits upon differentiated tumour cells [305,307,310,311]. Here, HGF is linked to neoplasm.