LGR5 and neoplasm: Selective ablation of Lgr5DTR CSCs in orthotopically implanted ApcMin/+KrasLSL-G12D/+Vil1Crep53−/−Smad4−/−Lgr5DTR/eGFP organoids demonstrated an indispensable role for Lgr5+ CSCs in the formation and maintenance of metastatic outgrowths, even though their ablation proved inefficacious in the primary tumour setting [297].