CLU and colitis: The revival stem cell pool is a rare, quiescent population in homeostasis, characterized by elevated expression of clusterin (Clu), Anxa1, Cxadr, and Basp1. While these Clu+ revival stem cells do not contribute to daily homeostatic renewal, they are mobilized and expanded following DTR-mediated ablation of Lgr5+ ISCs, irradiation, or DSS-induced inflammation and colitis.