By contrast, higher levels of TGFβ, such as those encountered in TGFβ-activated stroma, induced EMT—and not apoptosis—in BRAFV600E-mutant sessile serrated adenoma organoids, installing a mesenchymal CMS4 signature, whereas lower levels of TGFβ promoted progression to the CMS1 subtype [382]. The gene discussed is TGFB1; the disease is adenoma.