Feeding ApcMin/+ mice a high-fat diet shifted bile acid metabolism toward the increased production of tauro-β-muricholic acid and deoxycholic acid, which antagonize the function of the bile acid receptor FXR, stimulating Lgr5+ ISC proliferation, causing DNA damage and genomic instability, and facilitating adenocarcinoma progression. This evidence concerns the gene NR1H4 and adenocarcinoma.