Here, in addition to its roles in potentiating Wnt signalling, RSPO1 was found to stimulate the formation of complexes between LGR5 and the TGFβ type II receptor, augmenting the cytostatic and cytotoxic effects of TGFβ while effectively providing a selective pressure for silencing LGR5 during CRC progression [354]. The gene discussed is TGFB1; the disease is colorectal carcinoma.