When considered along with our previous findings that eosinophils undergo piecemeal degranulation in response to IAV [23] and that eosinophil peroxidase levels are elevated in the bronchoalveolar lavage fluid and lung homogenates in mice with asthma and influenza co-morbidity compared to asthma alone (unpublished data), the current results suggest that locally released granule proteins can act in concert to hinder IAV infectivity. This evidence concerns the gene EPX and influenza.