Loss of TIMP-3 in mouse promoted aberrant shedding of E-cadherin by ADAM10, another TIMP-3 target metalloproteinase, and consequent disruption the E-cadherin/beta-catenin complex from the cell surface, thus provoking enhanced hepatocyte cell death and liver failure in a murine model of hepatic ischemia/reperfusion injury [8]. The gene discussed is ADAM10; the disease is injury.