Several studies have found that high FGF23 can also predict the progression of CKD in non-diabetic patients with various underlying causes of nephropathy, including glomerulonephritis, interstitial nephritis, hypertensive renal disease, autosomal dominant polycystic kidney disease and non-diabetic CKD of unknown etiology [77,78,79]. The gene discussed is FGF23; the disease is kidney disorder.