In a large cohort of patients with various proteinuric kidney diseases (including group of patients with DKD), it has been documented that proteinuria (albuminuria) leads to phosphate retention independent on the GFR value and despite the increase in plasma FGF23 (although the association between albuminuria and phosphate retention was stronger for diabetics and patients with GFR of less than 45 mL/min/1.73 m2). This evidence concerns the gene FGF23 and kidney disorder.