Out of 17 urine and 7 plasma biomarkers analyzed (reflecting key processes involved in the progression of CKD: inflammation, fibrosis, angiogenesis, tubular function and injury, CKD-MBD) FGF23 was documented as the strongest predictor of end-stage renal disease in a cohort of diabetic patients with established DKD (eGFR of 43 ± 13 mL/min/1.73 m2 and mean albuminuria equalining 405 ± 673 mg/g) [82]. Here, FGF23 is linked to chronic kidney disease.