MiR-23a is induced by berberine treatment, a potent genotoxin that induces the accumulation of DSBs [149,150], in a p53-dependent manner in the HCC HepG2 cell, repressing NEK6 and inhibiting p53 repression induced by NEK6 [147] (Figure 3). Here, NEK6 is linked to hepatocellular carcinoma.