TXNRD1 and acute liver failure: It was noteworthy that, in mice with Trxr1/Gsr-null livers, ascorbate treatment: (i) increased death-rates from acute liver failure (Figure 1); (ii) increased hepatic histopathology and the abundance of necrotic hepatocytes (Figure 2); (iii) decreased levels of hepatic GSH (Figure 3 and Figure 4); and yet (iv) also apparently protected the livers from DNA damage as compared to untreated mice with TrxR1/Gsr-null livers (Figure 6).