APP and amyotrophic lateral sclerosis: Preclinical studies demonstrated the interaction between superoxide dismutase (SOD) and Aβ and evidence of the amyloid cascade has been reported [23] with an increase of sAPP in the CSF from ALS patients [24] and the post-mortem evidence of the over-expression of APP and Aβ in the hippocampi of ALS patients [17].