SOD1 and amyotrophic lateral sclerosis: For this purpose, those authors treated asymptomatic and symptomatic SOD-1 G93A mice with a monoclonal antibody able to interfere with β-secretase activity, avoiding the formation of intracellular or extracellular Aβ aggregates: treated asymptomatic ALS mice showed a delay of the onset of symptoms, motor failure and death; however, the same effects were not obtained in treated symptomatic ALS mice.