KRAS and neoplasm: It has been the best-characterized PDAC tumor-related gene due to the following reasons: (i) among human malignancies, PDAC has the highest frequency of KRAS mutations (up to 90%), (ii) the most frequent KRAS point mutations are located in codon 12, and (iii) alterations in this gene appear to occur at an early stage of pancreatic carcinogenesis.