GLA and cardiomyopathy: Although previous studies reported that FD cardiomyopathy can be recaptured with CRISPR/Cas9-edited GLA knockout in embryonic stem cells [31], one of them established the isogenic control [32] to provide definitive evidence in identifying the role of GLA IVS4 + 919G > A mutation in regulating FD cardiomyopathy and elucidating the mechanisms involved.