The alteration of albumin properties in HF and, in particular, its increased susceptibility to covalent adduction is partially supported by the fact that albumin protein conformation, binding activity, and enzymatic activity are greatly affected by covalent adductions as well as by physiopathological conditions such as aging and diseases (e.g., renal or hepatic dysfunction) http://dx.doi.org/10.1016/j.saa.2017.05.023 (accessed on 22 December 2020). This evidence concerns the gene ALB and hydrops fetalis.