RUNX2 and ocular melanoma: In CM, RUNX2, the early and master regulator of osteogenic differentiation [52], even in absence of osteogenic stimuli had a trend towards expression increment, with Log2(FC) = 0.9 at 21 days with respect to Log2(FC) of 3.0 and 2.9 in OM at 10 and 21 days, respectively.