ALB and neoplasm: In order to ascertain whether glycoproteins detected by LeMBA-MRM-MS in serum from dogs with HSA originated from the neoplastic endothelial cells or from adjacent tissues reacting to the presence and growth of the neoplastic cells, we applied LHC and IHC to tissues with HSA and other neoplasms, diagnosed by histopathology by veterinary pathologists, as well as to non-cancerous tissues.