ADNP and ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder: Activity dependent neuroprotective protein (ADNP) syndrome (OMIM: 615873) is an autosomal dominant neurodevelopmental disorder characterized by mild-to-severe intellectual disability (ID), autism spectrum disorder (ASD), speech and motor delays, and a variety of medical comorbidities [1,2,3].