Psychomotor delay, hypotonia, and intellectual disability, as well as heart defects, urogenital malformations, and characteristic cranio-facial dysmorphism are the main symptoms of dysmorphic syndrome associated with intergenic deletion in the Xq24 chromosome region including the <i>UBE2A</i> and <i>CXorf56</i> genes. This evidence concerns the gene UBE2A and Intellectual disability.