This imbalance in RANKL/OPG ratio is also a result of miR-21-5p function; miR-21-5p, whose oncogenic role has been variously described, was found to be upregulated in mesenchymal stem cells from MM patients (MM-MSCs) compared to normal mesenchymal stem cells (MSCs). The gene discussed is TNFSF11; the disease is Miyoshi myopathy.